• Acknowledgement This work was supported by grants from

  2021-09-06

  

  Acknowledgement This work was supported by grants from the National Natural Science Foundation of China (No.81802749), Shenzhen Healthcare Research Project (No.SZBC2017029), the Science and Technology Foundation of Shenzhen (JCYJ20170412155231633, JSGG20170414104216477), National Key Research and D

• Cucurbitacin I Not all metals are susceptible of being accum

  2021-09-06

  

  Not all metals are susceptible of being accumulated by insects. Tissue concentrations of essential metals like Cu and Zn are regulated in many insects and hence cannot be used to biomonitor metal pollution (Hare, 1992). A similar behaviour could explain the observed stability of Zn and Cu relative t

• br Introduction Initial studies of

  2021-09-06

  

  Introduction Initial studies of cancer metabolism in the early 1920s showed that the cancer phenotype for glucose metabolism is unique, with increased abilities to take up glucose and produce lactate, even under aerobic conditions [1]. This pathway, called aerobic glycolysis or the Warburg effec

• br Author contributions Animal experiments real time PCR

  2021-09-06

  

  Author contributions Animal experiments, real time PCR and western blots were performed at the Department of Physiology, CIMUS, University of Santiago de Compostela and Department of Cell Biology, Physiology and Immunology, Instituto Maimónides de Investigaciones Biomédicas (IMIBIC) / Reina Sofia

• Several studies have found that GPR

  2021-09-06

  

  Several studies have found that GPR55 possesses a distinct pharmacology from that of CB1 and CB2, and that only certain cannabinoids act at this receptor. In transfected Fructose expressing hGPR55, out of more than 20 synthetic and endogenous cannabinoids evaluated, only 2 compounds, SR141716A (Rim

• br Potential endogenous agonists of

  2021-09-06

  

  Potential endogenous agonists of GPR35 The first endogenously produced chemical that was shown to be able to activate GPR35 was the tryptophan metabolite kynurenic Boc-Phe-Osu [8]. When human GPR35 was expressed along with a mixture of promiscuous and chimeric G proteins 9, 10 (Box 1) in CHO cel

• br Materials and methods br Results

  2021-09-06

  

  Materials and methods Results Discussion Since 1990s, solving structures for most DNA glycosylases by X-ray crystallography significantly advanced mechanistic understanding of the catalytic activity and substrate specificity of this important class of DNA repair enzymes. However, static str

• br Transporter based brain targeting nano

  2021-09-03

  

  Transporter-based brain-targeting nano-DDS Drug delivery to the central nervous system (CNS) is still challenging due to the bloodbrain barrier (BBB)53., 54.. The BBB is a natural defense barrier protecting the MRT68921 from harmful substances. Since only selected, neutral, lipophilic small molec

• The general synthetic routes leading to aspartate and diamin

  2021-09-03

  

  The general synthetic routes, leading to aspartate and 2,3-diaminopropionate analogs, are shown in . As outlined in , aspartic PF-CBP1 hydrochloride analogs – were synthesized through standard carbodiimide-mediated coupling between an amine and an appropriately protected aspartic acid. It is worth

• The effect of GCK NES mutations on enzyme

  2021-09-03

  

  The effect of GCK-NES mutations on enzyme kinetics and protein stability might account for the hyperglycaemia that characterizes MODY2 patients, since reduced GCK activity would increase the threshold for glucose stimulated insulin release in beta-cells [31,37,49]. However, a more in depth functiona

• br Discussion The model of a

  2021-09-03

  

  Discussion The model of a NVU described by Mathias et al. (2018) has been implemented on the macro scale (see Kenny et al. (2018b)) via a 2D cerebral tissue slice coupled to a vascular tree. In particular, further communication within the tissue slice has been implemented via extracellular ion el

• br Acknowledgement This work was supported by National Scien

  2021-09-03

  

  Acknowledgement This work was supported by National Science Foundation (21475047, 21705051, 21874048), the Science and Technology Planning Project of Guangdong Province (2016B030303010), the Program for the Top Young Innovative Talents of Guangdong Province (2016TQ03N305) and the Foundation for H

• One effective approach to fine tuning

  2021-09-03

  

  One effective approach to fine-tuning the lipophilicity profile of FFA1 agonists is to ‘decorate’ the 3-phenylpropahoic MDL 800 scaffold with polar heterocyclic moieties. Alternatively, this scaffold could be replaced with heterocyclic isosteres (as in Takeda’s compounds 1,2 and 3 as well as Amgen’

• Hyperactivation of Notch pathway can give rise

  2021-09-03

  

  Hyperactivation of Notch1 pathway can give rise to transformation into T-ALL in murine models. In more than 50% of acute T-cell lymphoblastic leukemias oncogenic activating mutations of Notch1 have been detected and inactivation of Notch1 signaling impairs leukemia cell proliferation and promotes ap

• Verdinexor br Application of TIRFM to visualizing

  2021-09-03

  

  Application of TIRFM to visualizing exocytosis TIRFM was first used to visualize exocytosis from large secretory granules from chromaffin Verdinexor (Steyer et al., 1997). Before that, visualization of secretory organelle was strictly limited to a few exceptions, such as mast cell of mutant mice,

15940 records 573/1063 page Previous Next First page 上5页 571572573574575 下5页 Last page