• In various models histamine has

  2021-09-30

  

  In various models, histamine has been shown to induce chemotaxis. This was first appreciated over 40 years’ ago in studies with eosinophils (Clark et al., 1977). At that time, only histamine H1 and histamine H2 receptors were recognized and studies with ligands to these receptors indicated that neit

• br Conclusion Interactions between neurons and astrocytes de

  2021-09-30

  

  Conclusion Interactions between neurons and astrocytes depend on the spatial configuration of their contacts. Therefore, changes of astrocyte morphology may impact various physiological mechanisms ranging from glutamate uptake and potassium homeostasis to modulation of synaptic transmission and p

• Based on the precedent with other GlyT inhibitors such as

  2021-09-30

  

  Based on the precedent with other GlyT1 inhibitors such as , we evaluated both and for their ability to enhance prepulse inhibition (PPI) of the rodent acoustic startle response, a measure of sensorimotor gating known to be deficient in schizophrenic patients., In this amd3100 australia study ()

• In the present study participants reported a significant dec

  2021-09-30

  

  In the present study, participants reported a significant decrease in symptoms of anxiety and depression along with other symptoms of psychological distress and PTSD. These results are in agreement with a study in which hospitalized patients diagnosed with psychotic and mood disorders demonstrated s

• In vitro studies have shown that some antidepressant drugs

  2021-09-30

  

  In vitro studies have shown that some antidepressant drugs bind to NMDA receptors and inhibit the binding of NMDA receptor ligands [18]. Similarly, several research teams have reported that tricyclic antidepressants can modulate the release and/or uptake of glutamate [19]. In this study, we found th

• To confirm the in vitro findings atorvastatin or pravastatin

  2021-09-30

  

  To confirm the in vitro findings, atorvastatin or pravastatin was given to C57BL6/J mice fed with high fat diet. Doses of atorvastatin were set to be 6 mg/kg and 12 mg/kg, which were within clinical therapeutic doses. The results revealed that treatment of atorvastatin but not pravastatin impaired g

• The bFGF induced upregulation of both GR and MR

  2021-09-30

  

  The bFGF-induced upregulation of both GR and MR levels observed in our study raises a question regarding whether the simultaneous augmentation of the two receptors has a physiological and/or medical significance. It has been suggested that MR stimulates intracellular signaling pathways to minimize s

• The experiments indicate that a major component of the vasod

  2021-09-30

  

  The experiments indicate that a major component of the vasodilatation is due to antagonism of α 1-adrenoceptors. Evidence for α1-adrenoceptor antagonism is that vasodilatation was observed in Arecaidine but-2-ynyl ester tosylate preconstricted with α1-adrenoceptor agonists, phenylephrine or methoxa

• br Presenilins in protein trafficking proteolysis and degrad

  2021-09-30

  

  Presenilins in protein trafficking, proteolysis and degradation An obvious explanation for the role of presenilins and γ-secretase in protein trafficking and degradation is that many reported γ-secretase substrates are functionally involved in protein transport. For example, members of the mammal

• GPR which is also known

  2021-09-29

  

  GPR40, which is also known as FFA receptor 1 (FFAR1 or FFA1), was identified as an orphan receptor in the search for novel human galanin receptor (GALR) subtypes in 1997. Using reverse pharmacology approaches measuring calcium transients, GPR40 were deorphanized and characterized as being activated

• The other type of cell death that occurs in activated

  2021-09-29

  

  The other type of cell death that occurs in activated T Ivabradine HCl is caused by growth factor withdrawal following TCR-mediated activation, whereby most of the activated T cells die by apoptosis following the eradication of bacteria during an acute infection in order to reduce the level of cyto

• Ki16425 Furthermore rs is the one

  2021-09-29

  

  Furthermore, rs17171119 is the one which is studied well so far. One of the earlier studies has reported the clinical outcome and impact of EZH2 SNPs (rs41277434, rs3757441, rs2302427 rs9177211 T> C) (Crea et al., 2012). The only coding SNP ID rs2302427 has been studied in various diseases such as h

• RO5185426 In the present study LLY suppressed the

  2021-09-29

  

  In the present study, LLY-507 suppressed the proliferation of HGSOC RO5185426 via induction of apoptosis. Moreover, the colony-formation assay showed the long-term effects of SMYD2 inhibitors on HGSOC. It has been reported that LLY-507 induces an anti-tumor effect in several types of cancers in vit

• Long term effects of prolonged darkness on specific physiolo

  2021-09-29

  

  Long-term effects of prolonged darkness on specific physiological activities were also monitored at different leaf positions. Basically, stomatal conductance and CO2 assimilation were different at various leaf stages and were decreased or inhibited significantly within 24 h in all leaf positions upo

• In addition to lifestyle factors genetic factors may

  2021-09-29

  

  In addition to lifestyle factors, genetic factors may also influence the efficacy of antineoplastic drugs in breast cancer patients.16, 17 The HER2 gene contains several single nucleotide polymorphisms (SNPs). Two of the most investigated HER2 SNPs are Ile655Val (rs1136201) and Ala1170Pro (rs1058808

15940 records 558/1063 page Previous Next First page 上5页 556557558559560 下5页 Last page