• br Although killed whole cell oral cholera vaccines

  2019-04-20

  

  Although killed, whole-cell oral cholera vaccines (OCVs) have been known to be efficacious since 1986, and the bivalent whole-cell vaccine Shanchol has been licensed in India since 2009, OCV was not regarded as useful for controlling cholera outbreaks until recently. Many public health officials q

• br Acknowledgements br Introduction The

  2019-04-20

  

  Acknowledgements Introduction The chronic myeloproliferative neoplasms (MPN) comprise a group of clonal stem cell disorders with a high prevalence of the JAK2 V617F mutation (JAK2+) causing excessive production of mature blood cells. Transformation to acute myeloid leukemia (AML) is seen in 2–

• br Water the main component of Earth

  2019-04-20

  

  Water—the main component of Earth\'s ecosystems—concentrates some of the most worrying global concerns that have emerged during the Anthropocene. When it comes to health considered at a planetary level, the challenges related to water can be sorted into five main categories: pollution, access to w

• br Introdu o Conste que nossa percep o que

  2019-04-19

  

  Introdução Conste que nossa percepção é que as noções de reservas, guetos, ou comunidades remanescentes, não dão conta da realidade dessas reivindicações coletivas. Portanto, experiências como as dos Estados Unidos, Haiti, Cuba, República Dominicana, entre outros países com expressivo contingente

• Es por supuesto en La raz n populista y

  2019-04-19

  

  Es, por supuesto, en La razón populista y en textos sucesivos donde se desarrolla la teoría política del populismo en toda su complejidad Myoseverin partir de una serie de rupturas que constituyeron el posmarxismo de Laclau. Como el propio autor insinuaba en la obra de 1987, en esta teoría del popul

• In this study we analyzed the biological effects of two

  2019-04-19

  

  In this study, we analyzed the biological effects of two novel GATA2 mutations, which were identified in adult de novo AML patients. Materials and methods The diagnosis of AML was based on the morphology, histopathology, the expression of leukocyte differentiation XMU-MP-1 and/or the French–Ame

• The p MAPK pathway activates AP

  2019-04-19

  

  The p38 MAPK pathway activates AP1 to regulate transcription of TNF-α [32,33]. Our results show that EC inhibits the expression of total c-Jun and p-c-Jun in the lungs of LPS-challenged mice. This finding suggests that EC may inhibit TNF-α production in the lungs via the p38 MAPK–AP1 signaling pathw

• Venous gangrene treatment is based on therapeutic anticoagul

  2019-04-19

  

  Venous gangrene treatment is based on therapeutic anticoagulation and thrombolytic therapy. Low-molecular weight heparin is a good choice for patients with active cancer and for pregnant women with good renal function, whereas heparin is used as an alternative in patients with poor renal function. M

• br Conflict of interest statement br Acknowledgments The

  2019-04-19

  

  Conflict of interest statement Acknowledgments The authors would like to thank Dr. Bjørn Naume, and Dr. Erik Løkkevik from the Department of Clinical Oncology, the Norwegian Radium Hospital for their helpful comments. This study was supported by grants from the Norwegian Radium Hospital Founda

• br Mechanisms of arrhythmias Several schemes have been used

  2019-04-19

  

  Mechanisms of arrhythmias Several schemes have been used to classify the mechanisms of cardiac arrhythmias. Traditionally, these have been divided into nonreentrant and reentrant activity [11]. An alternative scheme divided them into those occurring at the cellular and tissue levels [12]. A dynam

• In silico prediction software SIFT PolyPhen CADD

  2019-04-19

  

  In silico prediction software, SIFT [51], PolyPhen2 [52], CADD [53], and other prediction systems are useful to evaluate a specific mutation which is detected in a patient. However, even if the in silico software predicts a mutation as pathogenic, we need to examine whether the genetic result is com

• These results have to be interpreted with

  2019-04-19

  

  These results have to be interpreted with respect to present trends in age at childbearing. Worldwide, adolescent fertility rates fell from 71 to 52 per thousand women aged 15–19 years between the 1970s and the 2000s. This A-443654 was seen in all regions, with the possible exception of Latin Ameri

• mth1 inhibitor In this context in Heather Zar and colleagues

  2019-04-19

  

  In this context, in , Heather Zar and colleagues report findings from the first study to assess the accuracy of Xpert MTB/RIF in young children presenting to a primary-care facility with symptoms of pulmonary tuberculosis. Primary analysis was done in 309 children in whom four samples (two induced s

• br This year marks years since

  2019-04-19

  

  This year marks 20 years since 189 countries signed the Beijing Declaration and Platform for Action and committed to prioritisation of women\'s empowerment and gender equality. Yet a recently released UN analysis shows that violence against women persists at “alarmingly high levels”. Worldwide, on

• Evidence of a variant induction of apoptosis to vorinostat

  2019-04-18

  

  Evidence of a variant induction of apoptosis to vorinostat in different DLBCL cell lines according to HAT mutational status implies that defects in CREBBP/EP300 could potentially explain the heterogeneous observations in clinical trials of vorinostat in NHL. These findings, however, need to be confi

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