• We agree that this method is an appropriate

  2019-05-21

  

  We agree that this method is an appropriate way to assess whether Buruli ulcer is over-represented in children, but this issue was not central to our study. We also felt that the introduction of external data, the quality of which we cannot assess and which might not be relevant to areas where Burul

• Performance based financing often highlighted in

  2019-05-21

  

  Performance-based financing, often highlighted in Rwanda\'s story, has had mixed results when applied elsewhere, partly because of breakdowns in execution. For example, the failure of the performance-based financing initiative in neighbouring Uganda was caused by challenges in setting targets, deliv

• A second methodological issue concerns

  2019-05-21

  

  A second methodological issue concerns the accuracy of the exposure measurement. Without accurate measurement, different methods for calculating attributable risk that are equivalent in theory are not guaranteed to give compatible results in practice. Previous experience with carcinogenic infections

• Non communicable disease behavioural risk factors such as to

  2019-05-21

  

  Non-communicable disease behavioural risk factors such as tobacco smoking, heavy alcohol consumption, physical inactivity, and unhealthy eating are socially patterned in high-income countries, with individuals of low socioeconomic status generally experiencing a higher burden of risk factors. Howeve

• The points of agreement of the models in the

  2019-05-21

  

  The points of agreement of the models in the study by Brady and colleagues make sense—eg, it is intuitive that the post-MDA prevalence of malaria is strongly related to the proportion of individuals in the purchase miniprep missed by an MDA campaign, as well as the pre-MDA endemic prevalence. Altho

• Conflicts of interest br Introduction Hepatocellular carcino

  2019-05-20

  

  Conflicts of interest Introduction Hepatocellular carcinoma (HCC) is one of the most common cancers and is the second leading cause of cancer death worldwide. In 2012, 782,500 new HCC cases and 745,500 deaths were caused by this persistent disease worldwide, with about 50% of the total number of

• Involvement of the ventricular myocardium can lead to

  2019-05-20

  

  Involvement of the ventricular myocardium can lead to delayed conduction or anatomical obstacles that are labile to ventricular tachyarrhythmia. Arrhythmias are independently predictive of sudden cardiac death (SCD) [9]. SCD is common in patients with cardiac AL amyloidosis, and prophylactic implant

• Second although it is an

  2019-05-20

  

  Second, although it is an important and biologically plausible refinement, risk-factor adjustment based on lack of access to improved water in rural areas and urban slums could be open to criticism, as the authors acknowledge. The imperfect relation between access to improved water and consumption o

• Despite taking hydroxyurea for months his leukocytosis splen

  2019-05-20

  

  Despite taking hydroxyurea for 6 months, his leukocytosis, splenomegaly, and constitutional symptoms were poorly controlled and his performance status and overall function had declined even further. There was little clinical benefit to gain by increasing the hydroxyurea dose further especially in th

• br Conclusion br Authors contribution br Competing interests

  2019-05-20

  

  Conclusion Authors’ contribution Competing interests Acknowledgments Case report Imatinib has radically changed prognosis in chronic-phase Chronic Myeloid Leukemia (CML), with 90% overall survival rate at 8yrs, and 40–70% of patients achieving a stable MMR [1]. Even better results hav

• br Water the main component of Earth s ecosystems

  2019-05-20

  

  Water—the main component of Earth\'s ecosystems—concentrates some of the most worrying global concerns that have emerged during the Anthropocene. When it comes to health considered at a planetary level, the challenges related to water can be sorted into five main categories: pollution, access to w

• Curiosamente las dos obras que pueden considerarse germinale

  2019-05-20

  

  Curiosamente, las dos obras que pueden considerarse germinales del pensamiento complejo, tales como Ciencia con consciencia e Introducción al pensamiento complejo, son obras de recopilación de trabajos dispersos, aunque ramificados lógicamente. Antes que tratados sistemáticos y elaborados desde el p

• br Methods br Results br Discussion A baumannii

  2019-05-20

  

  Methods Results Discussion A. baumannii remains one of the most common nosocomial pathogens and frequent causes of outbreaks in burn wound infections. Unfortunately, most of the isolates are resistant to antimicrobial agents. β-Lactamases are microbial enzymes that hydrolytically inactivate

• Next we evaluated the interatrial and interatrioventricular

  2019-05-20

  

  Next, we evaluated the interatrial and interatrioventricular synchrony because a long contraction time between the right and left atria was observed during the SSA procedure, dissection of the atrial septum, and patch closure. We were primarily concerned with determining whether the timing of the le

• It is possible that this

  2019-05-18

  

  It is possible that this contradiction may be due to referral bias in the studies of Brugada et al. [20,21]. Second, it is possible that time of day influences the results of PES. The magnitude of ST-segment elevation in the right precordial leads in BS varies spontaneously over days and during the

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