• SM-164 and the Interplay of IAP Antagonism with Apoptotic...

  2025-09-19

  This article explores the unique role of SM-164, a bivalent Smac mimetic, as an IAP antagonist for cancer therapy. It examines how SM-164 modulates apoptosis induction in tumor cells, while contextualizing its mechanism within emerging insights into regulated cell death pathways.

• SM-164: Mechanistic Insights into IAP Antagonism and Apop...

  2025-09-18

  Explore the mechanistic underpinnings of SM-164, a bivalent Smac mimetic and potent IAP antagonist for cancer therapy, focusing on its role in apoptosis induction in tumor cells and the caspase signaling pathway. This article provides n

• GFP Quantitation Kit MT SGL encourages a individual

  2025-03-03

  

  MT-SGL encourages (a) individual feature selection based on the utility of the features across all tasks with ℓ2,1-norm and (b) task specific group selection based on the utility of the group with G2,1-norm, i.e., GFP Quantitation Kit regions of interest (ROI) for that task. Unlike basic SGL for re

• Introduction hydroxytryptamine HT is found throughout the bo

  2025-03-03

  

  Introduction 5-hydroxytryptamine (5-HT) is found throughout the body and influences smooth muscle activity in various tissues including the intestine, vasculature and urinary NF-κB inhibitors library (Kim and Camilleri, 2000, Klarskov and Horby-Petersen, 1986, Mohammad-Zadeh et al., 2008). The cur

• Renal fibrosis is regarded as the

  2025-03-03

  

  Renal fibrosis is regarded as the final common pathway for most forms of progressive renal disease, and mouse UUO is a widely accepted experimental model of renal injury leading to extreme fibrosis localized to the interstitial compartment. A-306989 attenuated the mRNA expression levels of several k

• Additionally regulation of GPCR heteromerization by specific

  2025-03-03

  

  Additionally, regulation of GPCR heteromerization by specific ligands may depend not only on the affinity of ligands for receptors, but also on presence of different interacting proteins co-localizing with the receptors in the specific cell, which may induce some conformational changes and contribut

• Secondly leptin has been shown to enhance

  2025-03-01

  

  Secondly, leptin has been shown to enhance aromatase mRNA expression, aromatase content and its enzymatic activity in epithelial breast cancer isx by inducing promoters II and I.3 via an enhanced binding of transcription activator protein 1 (AP-1) complex to specific DNA sites in the promoter regio

• In this study we first determined whether AIF in bovine

  2025-03-01

  

  In this study, we first determined whether AIF in bovine LT muscle is expressed and the mitochondria released AIF-mediated apoptosis during postmortem aging. For apoptotic issues, the mitochondrial outer membrane is permeabilized, and AIF translocates to the cytosol and to the nucleus, where it indu

• Mechanistically it was soon realized

  2025-03-01

  

  Mechanistically, it was soon realized that in undead cells, Dronc promotes the activation of Jun-N-terminal kinase (JNK) signaling as the major inducer of AiP [25], [28] (Fig. 2B,C). However, it has been unknown for a long time how active Dronc promotes JNK signaling. Recently, it was reported that

• br Antifungal resistance what is in a name

  2025-03-01

  

  Antifungal resistance, what is in a name? Antifungal resistance is an emerging and hot topic in the field of medical mycology. Microbiological resistance is identified by determining minimal inhibitory concentrations (MICs) in vitro for a given antifungal and interpreting this value according to

• br Acknowledgements br Introduction The angiogenic ocular

  2025-03-01

  

  Acknowledgements Introduction The angiogenic ocular conditions represent the most common cause of blindness in developed countries [1]. It can affect all ages, for example, retinopathy of prematurity (ROP) in infants [2], [3], diabetic retinopathy (DR) [4] in working age adults and age-related

• In conclusion our study has identified a spl http

  2025-03-01

  

  In conclusion, our study has identified a splice site hiv protease inhibitor (c.1769-1G > C) in the AR gene from two patients with complete androgen insensitivity syndrome. The c.1769-1G > C mutation may provide us new insights into the molecular mechanism involved in splicing defects underlying CA

• Intracellular Signaling Cascades From ligand

  2025-03-01

  

  Intracellular Signaling Cascades. From ligand sensitization to translation of genes, all cellular processes are dependent on the intracellular levels and activity of partners involved in the signaling pathway. These signaling events lead to critical post-translational modifications including phospho

• In our sequential model for tau

  2025-03-01

  

  In our sequential model for tau and Aβ deposition, we included the tau deposition in the medial temporal gap junction in the absence of Aβ deposition, which is a pathological definition of primary age-related tauopathy (PART). Although the tau pathologies in PART and AD are almost identical in thei

• s3i br Alzheimer s disease AD is an irreversible

  2025-03-01

  

  Alzheimer’s disease (AD) is an irreversible, age-associated neurodegenerative disorder that is characterized by progressive memory loss and cognitive decline. AD is also the leading cause of dementia, accounting for 5 million cases in the United States and 44 million cases worldwide. In 2015, AD c

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