• In this study we analyzed the biological effects of two

  2019-04-19

  

  In this study, we analyzed the biological effects of two novel GATA2 mutations, which were identified in adult de novo AML patients. Materials and methods The diagnosis of AML was based on the morphology, histopathology, the expression of leukocyte differentiation XMU-MP-1 and/or the French–Ame

• The p MAPK pathway activates AP

  2019-04-19

  

  The p38 MAPK pathway activates AP1 to regulate transcription of TNF-α [32,33]. Our results show that EC inhibits the expression of total c-Jun and p-c-Jun in the lungs of LPS-challenged mice. This finding suggests that EC may inhibit TNF-α production in the lungs via the p38 MAPK–AP1 signaling pathw

• Venous gangrene treatment is based on therapeutic anticoagul

  2019-04-19

  

  Venous gangrene treatment is based on therapeutic anticoagulation and thrombolytic therapy. Low-molecular weight heparin is a good choice for patients with active cancer and for pregnant women with good renal function, whereas heparin is used as an alternative in patients with poor renal function. M

• br Conflict of interest statement br Acknowledgments The

  2019-04-19

  

  Conflict of interest statement Acknowledgments The authors would like to thank Dr. Bjørn Naume, and Dr. Erik Løkkevik from the Department of Clinical Oncology, the Norwegian Radium Hospital for their helpful comments. This study was supported by grants from the Norwegian Radium Hospital Founda

• br Mechanisms of arrhythmias Several schemes have been used

  2019-04-19

  

  Mechanisms of arrhythmias Several schemes have been used to classify the mechanisms of cardiac arrhythmias. Traditionally, these have been divided into nonreentrant and reentrant activity [11]. An alternative scheme divided them into those occurring at the cellular and tissue levels [12]. A dynam

• In silico prediction software SIFT PolyPhen CADD

  2019-04-19

  

  In silico prediction software, SIFT [51], PolyPhen2 [52], CADD [53], and other prediction systems are useful to evaluate a specific mutation which is detected in a patient. However, even if the in silico software predicts a mutation as pathogenic, we need to examine whether the genetic result is com

• These results have to be interpreted with

  2019-04-19

  

  These results have to be interpreted with respect to present trends in age at childbearing. Worldwide, adolescent fertility rates fell from 71 to 52 per thousand women aged 15–19 years between the 1970s and the 2000s. This A-443654 was seen in all regions, with the possible exception of Latin Ameri

• mth1 inhibitor In this context in Heather Zar and colleagues

  2019-04-19

  

  In this context, in , Heather Zar and colleagues report findings from the first study to assess the accuracy of Xpert MTB/RIF in young children presenting to a primary-care facility with symptoms of pulmonary tuberculosis. Primary analysis was done in 309 children in whom four samples (two induced s

• br This year marks years since

  2019-04-19

  

  This year marks 20 years since 189 countries signed the Beijing Declaration and Platform for Action and committed to prioritisation of women\'s empowerment and gender equality. Yet a recently released UN analysis shows that violence against women persists at “alarmingly high levels”. Worldwide, on

• Evidence of a variant induction of apoptosis to vorinostat

  2019-04-18

  

  Evidence of a variant induction of apoptosis to vorinostat in different DLBCL cell lines according to HAT mutational status implies that defects in CREBBP/EP300 could potentially explain the heterogeneous observations in clinical trials of vorinostat in NHL. These findings, however, need to be confi

• Evidence supporting the benefit of dexrazoxane

  2019-04-18

  

  Evidence supporting the benefit of dexrazoxane as cardioprotective therapy in adults with acute leukemia are scant [11]. However, there is a significant need for cardioprotective therapy, particularly in older individuals with preexisting cardiovascular disorders and/or prior anthracycline exposure,

• According to most published reports patients with

  2019-04-18

  

  According to most published reports, patients with Twiddler\'s syndrome are usually diagnosed due to some type of sudden device malfunction [1–4,6–15]. Early detection of this condition can also be achieved with a home monitoring system [8]. The case presented is a rare one in which Twiddler\'s synd

• The authors would like to thank

  2019-04-18

  

  The authors would like to thank Ms. Fang-Ju Sun for her help with statistical analysis. This study was supported by a research grant from Mackay Memorial Hospital (MMH10466). Introduction Cancer of the Ro3306 (CC) is the second most common cancer affecting women worldwide, and about 86% of CC c

• Introduction Several types of cancers including

  2019-04-18

  

  Introduction Several types of cancers, including those originating in the breast, prostate, and lung, have a propensity to metastasize to the bones [1,2]. Bone metastases severely impair skeletal metabolism, and result in important clinical sequelae, such as excruciating chronic bone pain and the s

• Tacrolimus br Materials and methods This study included WCD

  2019-04-18

  

  Materials and methods This study included WCD patients with high risk of SCD but did not meet the eligibility criteria for immediate Tacrolimus of an implantable cardioverter defibrillator (ICD). Current guidelines endorse indications for WCD therapy [5]. Patients with low left ventricular eject

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