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O processo de sele o
2019-04-28
O processo de seleção é crucial, pois elastase inhibitor ‘escolhida’ será a responsável, nos próximos cinco anos, pela gestão do hospital determinado, decisão publicada em Diário Oficial. Dois aspectos são merecedores de atenção. Inicialmente, a decisão unilateral de escolha pelo Secretário de Saúde
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Splicing machinery dysfunctions have been associated
2019-04-28
Splicing machinery dysfunctions have been associated to CLL, in particular gene mutations (splicing factor 3B subunit 1) which are present in about 15% of patients . To our knowledge, no gene mutation has ever been detected in CLL. In order to broaden our knowledge on the frequency of splicing mu
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hmg-coa reductase inhibitor br Conclusion br Introduction Mu
2019-04-28
Conclusion Introduction Multiple myeloma is a malignant plasma cell disorder, comprising approximately 10% of all haematological malignancies, and its incidence is increasing [1]. The pathogenesis is complex, culminating in malignant transformation of clonal plasma cells. The aetiology is not
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br Cholera remains a serious global public health
2019-04-26
Cholera remains a serious global public health problem, disproportionately affecting poor individuals, causing illness and death for thousands of people each year. Cholera cases are on the rise, with 47% more cases reported to WHO in 2014 than in 2013. Innovative approaches to control the disease
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We have received funding from the Wellcome Trust to develop
2019-04-26
We have received funding from the Wellcome Trust to develop a global atlas of podoconiosis. We aim to advance new knowledge on the geographical distribution and spatial epidemiology of the disease. A first step in this work will be to establish the geographical absence of disease by applying an evid
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br Ablation strategies from targeted to homogenization The t
2019-04-26
Ablation strategies – from targeted to homogenization The techniques and principles originally developed in postinfarction scar have been translated and applied to patients with various etiologies of fibrosis and confluent scar including Chagasic cardiomyopathy, nonischemic cardiomyopathy, arrhyt
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br Conflict of interest br Introduction Nasopharyngeal
2019-04-26
Conflict of interest Introduction Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells that line the surface of the nasopharynx. It is a commonly found tumor of the head and neck region in adults, and its incidence varies widely in different regions. It has been observed
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br Conclusions br Limitation br Acknowledgments This researc
2019-04-26
Conclusions Limitation Acknowledgments This research was supported in part by the China Postdoctoral Science Foundation (Nos. 2013M542478 and 2015T81139), a Grant (no. 2014FB059) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical Uni
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We used MRI images taken to weeks after a crisis
2019-04-26
We used MRI images taken 1 to 8 weeks after a crisis to explore basal ganglion involvement and found restricted caffeic acid phenethyl ester at the basal ganglion. This finding suggests that cytotoxic damage to the basal ganglion persists post-crisis. When MRI images were obtained much longer after
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br Mechanisms of ventricular fibrillation electrical storm i
2019-04-26
Mechanisms of ventricular fibrillation/electrical storm in the Brugada syndrome patients One of the most consistent features of BrS is that premature ventricular contraction (PVC), which triggers VF, is almost always short-coupling [3,4]. An interesting phenomenon is that many of the VF episodes
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Current ASCO recommendations suggest initiating
2019-04-26
Current ASCO recommendations suggest initiating bisphosphonate therapy in myeloma when there is evidence of bone involvement [124]. The optimal duration and frequency of bisphosphonate therapy for myeloma are not well understood and are currently being studied. All randomized, placebo-controlled tri
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De esta manera los estados latinoamericanos se han
2019-04-25
De esta manera, los estados latinoamericanos se han redefinido desde aquello que puede denominarse cautela y desconfianza. Dichos estados son la materialización de la desconfianza histórica, de la amplitud del margen del conocimiento, de la apreciación de que no todo va bien y por supuesto, de una “
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Recordemos que en diciembre de
2019-04-25
Recordemos que en diciembre de 1938 se celebró en Lima la Octava Conferencia Internacional de los Estados Americanos, donde se analizó la Segunda Guerra Mundial y las posibles consecuencias para América, así como el rol de Estados Unidos, aunque no se aprobó ninguna acción colectiva. La Declaración
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A second methodological issue concerns the accuracy of the
2019-04-25
A second methodological issue concerns the accuracy of the exposure measurement. Without accurate measurement, different methods for calculating attributable risk that are equivalent in theory are not guaranteed to give compatible results in practice. Previous experience with carcinogenic infections
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The incidence of AF in Japan was also reported
2019-04-25
The incidence of AF in Japan was also reported from an early cohort of the Hisayama Study [32] in the period between 1961 and 1984. Similar to the reports from Western countries, the incidence of AF increased with age in both men and women (Fig. 7) [32]. In a recent report of an observational cohort
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