• Materials and methods br Results br Discussion Hydroxylation

  2019-09-26

  

  Materials and methods Results Discussion Hydroxylation of proline in bacterial that is one of the oxygen-requiring metabolic reactions, which needs efficient oxygen. Oxygen supply is always a rate-limiting step for tyrosinase production even though pure oxygen is purged in a bioreactor (37).

• Since protein kinase CK has over known substrates we examine

  2019-09-26

  

  Since protein kinase CK2 has over 300 known substrates we examined if the inhibitory effects described above could also be detected using another substrate. Therefore, we employed the synthetic peptide RRRADDSDDDDD which is often used in CK2 inhibitory studies. Quite contrary to the phosphorylation

• PI K Akt signaling pathway is known in modulating

  2019-09-26

  

  PI3K/Akt signaling pathway is known in modulating cell apoptotic process (Saurus et al., 2015). To study the contribution of PI3K/Akt signaling pathway in ERRγ-mediated anti-apoptotic effect in podocytes, we examined phosphorylation of Akt and expression of PI3K subunits p110α and p85α via qRT-PCR a

• meclozine br Conclusion The past few

  2019-09-26

  

  Conclusion The past few years have witnessed substantial progress in understanding the structural mechanisms of substrate recognition and the reactions catalyzed by the O-GlcNAc-cycling enzymes, but more work remains. In particular, future research will be needed to establish how OGT and OGA inte

• Herbal products may alter the metabolism of certain drugs

  2019-09-26

  

  Herbal products may alter the metabolism of certain drugs and, likewise, the metabolism of components of herbal products may be altered by some drugs, specifically those that affect cytochrome P450 Prednisolone mass (CYP). These can bring about an alteration of the pharmacokinetics and pharmacologi

• In addition to tissue resident stromal

  2019-09-25

  

  In addition to tissue-resident stromal and myeloid cell populations, ILCs also readily engage in positive-feedback loops with myeloid 43 7 recruited from the circulation. TNF-α produced by inflammatory monocytes recruited to the lungs of mice infected with Klebsiella pneumoniae markedly increased t

• A structural explanation for how

  2019-09-25

  

  A structural explanation for how RBR RING1s handle their bound E2~Ubs differently from canonical RINGs has not been readily apparent. Only a few residue positions are strongly conserved in RING and RING1 domains, most of which are zinc-coordinating Cys and histidine residues. A key position in canon

• Consistent with previous simulations on

  2019-09-25

  

  Consistent with previous simulations on the DFG-Asp-out/-in interconversion of Abl kinase, we only observe the DFG flip with protonated Asp747 (Shan et al., 2009). We showed previously that the pKa for the DFG-Asp in Abl is elevated at 6.5. Further “constant pH” simulations whereby protonation event

• br Results and Discussion br

  2019-09-25

  

  Results and Discussion Materials and Methods Acknowledgements Introduction Among the solid tumors, Prostate cancer (PCa) has been one of the most frequently diagnosed malignancy in men and the second male\'s cancer related deaths in the developed countries [1]. In China, the incidence an

• The mechanism by which these HIV PIs

  2019-09-25

  

  The mechanism by which these HIV-PIs impair skeletal muscle palmitate transport and oxidation has been partially elucidated. CD36 (also referred to as fatty Miglitol kinase translocase; FAT) is a transmembrane protein involved in the transport of long-chain fatty acids (LCFA) across cellular membra

• A769662 Tinnitus Met carriers with severe hearing loss perce

  2019-09-25

  

  Tinnitus Met carriers with severe hearing loss perceive their tinnitus as being louder, which is associated with increased activity in the PHC, increased PHC→pgACC connectivity, as well as decreased pgACC→PHC connectivity. This indicates that Met carriers with severe hearing loss have increased tinn

• Bovine collagen type II a fibrillar collagen mainly

  2019-09-25

  

  Bovine collagen type II, a fibrillar collagen mainly found in cartilage, comprises 24 potentially glycosylated lysine residues within its collagen domain. Detailed analysis revealed that 22 out of 23 of these lysine residues are hydroxylated and carry variable numbers of Gal(β1-O) and Glc(α1-2)Gal(β

• br EphB as a therapeutic target in cancer

  2019-09-25

  

  EphB4 as a therapeutic target in cancer Eph receptors and ephrins are promising new therapeutic targets in cancer. Various strategies have been employed to evaluate the interference of tumor-promoting effects or the enhancement of tumor suppressive effects. The inhibition of the Eph-ephrin system

• Increased leukocyte trafficking and infiltration

  2019-09-25

  

  Increased leukocyte trafficking and infiltration of the vascular wall are thought to provide a key stimulus for SMC activation and subsequent neointima formation in response to vascular injury [19], [20]. The essential trigger regulating the accumulation of leukocytes in the vessel wall is the upreg

• br Cytochrome P monooxygenases Cytochrome P monooxygenases P

  2019-09-25

  

  Cytochrome P450 monooxygenases Cytochrome P450 monooxygenases (P450s) belong to one of Nature’s most versatile group of enzymes for C–H functionalization and are able to perform challenging regioselective and stereoselective activations of remote, unactivated C(sp3)–H bonds, for which there are o

15974 records 955/1065 page Previous Next First page 上5页 951952953954955 下5页 Last page