• Uracil residues incorporated into DNA exist transiently

  2020-03-18

  

  Uracil residues incorporated into DNA exist transiently since they are subject to removal by the multi-step uracil-initiated DNA praziquantel biltricide excision repair (BER) process [2], [14]. In E. coli, uracil-DNA BER is initiated by uracil-DNA glycosylase (Ung), which catalyzes the hydrolytic c

• mitoxantrone In conclusion adipose PGD suppressed the

  2020-03-18

  

  In conclusion, adipose PGD2 suppressed the lipolysis by decreasing the intracellular cAMP level through DP2R. Therefore, PGD2 enhanced adipocyte differentiation (lipid accumulation) through both repression of the lipolysis via DP2R and activation of the lipogenesis via PPARγ. Thus, L-PGDS and DP2R a

• Recently several Pt IV complexes as prodrugs have been desig

  2020-03-18

  

  Recently, several Pt(IV) complexes as prodrugs have been designed and studied to enhance anti-tumor efficacy of traditional Pt(II) drugs, improving their cellular uptake and blood-circulation time [26], [27], [28], [29]. Compared with their Pt(II) counterparts, six-coordinated Pt(IV) complexes with

• Alzheimer s disease AD is a chronic progressive neurodegener

  2020-03-18

  

  Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative disorder of the ampk activator which is considered a leading cause of dementia and affects 20–30 million people worldwide. Presently, a suitable treatment and prevention strategy against AD is hardly available. Various studies hav

• bcl-2 inhibitor br torsion is a urological

  2020-03-18

  

  torsion is a urological emergency that may occur at any age. To establish blood flow surgical detorsion is required in most cases while detorsion can sometimes be achieved by hand assistance. Regardless of the correction method 2 phases (I/R) negatively affect germ cells. The torsion phase decreas

• br Methods br Discussion In a recent survey among high

  2020-03-18

  

  Methods Discussion In a recent survey among 2625 high risk patients on atorvastatin, 10.5% of patients achieved an LDL-target of Beta-Lapachone level for improvement of acceptance and adherence to effective lipid lowering therapy are warranted to maximize the benefits of standard treatment opt

• The Penicillium strain used in this work was

  2020-03-18

  

  The Penicillium strain used in this work was isolated from Atlantic forest soil and previously screened as lipase producer (Tauk-Tornisielo et al., 2005). The immobilization was previously evaluated using hydrophobic supports, i.e. agarose based butyl-(But), phenyl-(Phe) and octyl-Sepharose (Oct), a

• The elastase induced injury model has been shown

  2020-03-18

  

  The elastase-induced injury model has been shown to produce airspace enlargement, and increases in lung volume and compliance that are similar to those observed in human patients (Hantos et al., 2008, Hamakawa et al., 2011). Thus, this model, which has been used to study emphysema, should be adequat

• The total reduced glutathione content

  2020-03-18

  

  The total reduced glutathione content was determined in both 4 aminopyridine to examine whether retinol was decreasing glutathione concentrations and thus decreasing the conjugation of NAPQI. Total hepatic (3.9±0.3 vs 4.9±1.0 μmol/g, retinol vs untreated, respectively) and renal (0.4±0.1 vs 0.2±0.1

• Although shoulder dub off on gun

  2020-03-18

  

  Although shoulder dub-off on gun drills has significant influence on chip transportation behavior, most commercial gun drills adhere to a fixed design of 20° that has limited scientific basis. To determine the effects of shoulder dub-off on chip evacuation, 5 different angles ranging from 0° to 30°

• We aim to apply the

  2020-03-18

  

  We aim to apply the same technology to target other collagen-binding proteins using motifs from collagens that are specific for other receptors or matrix components. Previously, we synthesized THP libraries, called Toolkits, composed of an active guest sequence flanked by five GPP host triplets that

• br Materials and methods br Results br Discussion

  2020-03-17

  

  Materials and methods Results Discussion TP has aroused extensive explorations because of its potent anti-inflammatory, immune-suppressive and antitumor activities. Notwithstanding these, TP has yet to enter Phase II clinical trials owing to its severe toxicity (Zhou et al., 2012). TP could

• The importance of mitochondria as site of aerobic oxidation

  2020-03-17

  

  The importance of mitochondria as site of aerobic oxidation of metabolic fuels, such as FA, has been recognized for a long time. It has been observed that the number of mitochondria may vary in response to cellular metabolic requirements and hormonal environment (Gao et al., 2014). In order to susta

• AAK1 dual inhibitor It is interesting that of

  2020-03-17

  

  It is interesting that of the control groups, female TG controls only had significantly higher MB-COMT protein than non-TG male controls (Supplemental Table 9, P = 0.005), while these two groups have almost equal expression of S-COMT protein (8.54- vs. 8.34-fold) and their COMT enzyme activity is al

• br Introduction The ubiquitination status of

  2020-03-17

  

  Introduction The ubiquitination status of a target protein is achieved via a delicate balance between two opposing forces: ubiquitin E3 ligases and DUBs. It has been postulated that the majority of proteins in a cell are regulated and modified by ubiquitin at some point (Hershko and Ciechanover,

15251 records 811/1017 page Previous Next First page 上5页 811812813814815 下5页 Last page