• It has been reported that the ECD of

  2021-02-25

  

  It has been reported that the ECD of DDRs require dimerization and/or oligomerization for binding to collagen.,, Here, we have established using SPR that antibody-mediated oligomerization of DDR2-Fc significantly enhances its binding to immobilized collagen type 1. Our results are consistent with ea

• br Experimental Procedures Further details and an outline of

  2021-02-25

  

  Experimental Procedures Further details and an outline of resources used in this work can be found in Supplemental Experimental Procedures. Introduction In response to T cell-dependent (TD) antigen stimulation, antigen-specific Ketanserin migrate to the periphery of B cell follicles and inte

• Introduction The Discoidin Domain Receptors DDRs

  2021-02-24

  

  Introduction The Discoidin Domain Receptors (DDRs), comprising DDR1 and DDR2, are collagen-binding receptor tyrosine kinases (RTKs) that function as microenvironmental sensors at the interface of the extracellular matrix and the intracellular signal transduction machinery [1]. In response to ligand

• Orange spotted grouper Epinephelus coioides is a coral

  2021-02-24

  

  Orange-spotted grouper (Epinephelus coioides) is a coral reef fish with a high commercial value in China and Southeast Asian countries. However, in recent years, various outbreaks of viral diseases have affected the grouper aquaculture industry (Wei et al., 2010). Specifically, Singapore grouper iri

• MNs can be obtained from iPSCs

  2021-02-24

  

  MNs can be obtained from iPSCs, using signaling molecules such as retinoic Cinchonidine mg (RA) and Sonic hedgehog (Shh) (Table S1).4, 5, 12, 23, 24, 25, 26, 27, 28, 29 These methods rely on developmental principles and require changing the combinations of signaling molecules at multiple steps, whi

• br Materials and methods br Results

  2021-02-24

  

  Materials and methods Results Discussion Human Chk, a member of the Csk-family, was initially cloned from two different megakaryocytic cell lines [2], [3]. Structural comparison of human Chk with human Csk shows that human Chk has the additional N-terminal unique domain [2], [3], [25]. Chk

• br Conclusions br Statement of authorship br Nonaneurysmal s

  2021-02-24

  

  Conclusions Statement of authorship Nonaneurysmal subarachnoid hemorrhage (NA-SAH) differs from aneurysmal subarachnoid hemorrhage (SAH) in both clinical course and outcome. In spite of many reports and case series since the first description in 1985, the etiology of NA-SAH remains uncertain

• The N B method has the overall advantage that it

  2021-02-24

  

  The N&B method has the overall advantage that it is not restricted to certain dyes specific for energy transfer [55], and is also able to detect higher order receptor DBIBB receptor on the focal point in living cells. Conclusion The N&B method has shown to be a powerful tool to locate and quant

• In contrast to drospirenone dydrogestrone acts rather neutra

  2021-02-24

  

  In ARCA Cy3 EGFP mRNA to drospirenone dydrogestrone acts rather neutral at the aldosterone-, glucocorticoid- and androgen-receptor [12]. This indicates that the assessment of a ‘net-overall effect’ on the vascular system is very difficult based on the often discussed ‘partial effects’ of the proges

• A putative SHBG receptor SHBG R has

  2021-02-24

  

  A putative SHBG NCT-503 (SHBG-R) has been postulated for about thirty years [66], [69], [70]. The characterization of this receptor has been researched by several groups. There are different ideas on how this receptor works. On the one hand Fortunati et al. provide evidence that SHBG is already bou

• In some of our studies we examined the occurrence of

  2021-02-24

  

  In some of our studies we examined the occurrence of ERβ and SHBG and a possible colocalization between them. Fig. 5 shows that there is no big difference in the occurence of ERβ after short time (A) as well as long time (B) treatment with E2. We can find the receptor at the cell membrane as well as

• GSK1904529A To further investigate mechanisms of

  2021-02-24

  

  To further investigate mechanisms of rXCI, we generated female ESCs with a homozygous RlimKO. We found that these GSK1904529A undergo XCI in vivo but that XCI in vitro is strongly influenced by culture conditions, including both method of differentiation and O2 levels. Our results demonstrate Rlim-

• Results are expressed as mean s

  2021-02-24

  

  Results are expressed as mean±s.e.m. Paired or unpaired Student's t test was used for comparisons between 2 groups and one-way ANOVA followed by Bonferroni's post-test for more groups. Statistical significance was assigned if p Results and discussion Variations in [Ca2+]i in cardiomyocytes loaded

• br Materials and methods br Results and discussion

  2021-02-24

  

  Materials and methods Results and discussion Summary Acknowledgments We thank Muhammad Anwar for animal rearing and surgery. We also thank Michael M. Myers for editing. Finally, we thank David Hirschberg for his technical advice. Funding for this project was provided by the Einhorn Famil

• br Marginal zone lymphoma Marginal zone

  2021-02-24

  

  Marginal zone lymphoma Marginal zone lymphoma (MZL) comprises three lymphoma entities that arise from the marginal zone surrounding the germinal center: extranodal MZL or mucosa-associated lymphoid tissue (MALT), splenic MZL, and nodal MZL. Deep sequencing of nodal MZL patients found that 5/35 (1

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